An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels.

نویسندگان

  • Bart L Haagmans
  • Judith M A van den Brand
  • V Stalin Raj
  • Asisa Volz
  • Peter Wohlsein
  • Saskia L Smits
  • Debby Schipper
  • Theo M Bestebroer
  • Nisreen Okba
  • Robert Fux
  • Albert Bensaid
  • David Solanes Foz
  • Thijs Kuiken
  • Wolfgang Baumgärtner
  • Joaquim Segalés
  • Gerd Sutter
  • Albert D M E Osterhaus
چکیده

Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.

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عنوان ژورنال:
  • Science

دوره 351 6268  شماره 

صفحات  -

تاریخ انتشار 2016